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Glycemic category (normoglycemia, prediabetes or type 2 diabetes) was determined by investigators on the basis of available information (for example, medical records, concomitant medication, and blood glucose variables) and in accordance with American Diabetes Association criteria 30 , which for prediabetes includes fasting plasma glucose levels of 100 mg dl 1 (5.6 mmol l 1 ) to 125 mg dl 1 (6.9 mmol l 1 ) or HbA 1c levels of 5.76.4% (3947 mmol l 1 ), and for type 2 diabetes includes fasting plasma glucose levels of 126 mg dl 1 (7.0 mmol l 1 ) or HbA 1c levels 6.5% (48 mmol l 1 )

People may skip workouts, lose motivation, or have more difficulty staying active throughout the day

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The 46 hour window is derived from NNMT inhibition kinetics (90120 minutes to peak effect) and AMPK activation duration (68 hours post-MOTS-c injection)

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Effect of mecobalamin on diabetic neuropathies: Beijing Methycobal Clinical Trial Collaborative Group